Hereditary angioedema
Danazol, How does it work?
How does it work?
Danazol capsules contain the active ingredient danazol, which is a synthetic steroid hormone resembling a group of natural sex hormones (androgens) found in the body. Danazol acts on the pituitary gland in the brain, a gland that controls the amounts of hormones that are produced by the body.
Danazol inhibits the production of hormones called gonadotrophins by the pituitary gland. Gonadotrophins normally stimulate the production of sex hormones such as oestrogen and progestogen, which are responsible for body processes such as menstruation and ovulation.
By decreasing the production of these sex hormones, danazol can be used to treat disorders that are associated with disturbances in hormone production.
Danazol is used to treat endometriosis, a condition where the tissue that normally lines the womb grows on other organs outside the womb. The growth of endometriotic tissue is under hormonal influence, and danazol is used to control the fluctuations in hormone levels that stimulate the growth of this tissue.
Breast tissue is also under the control of sex hormones, and danazol can be used to relieve severe breast pain and tenderness in benign fibrocystic breast disease.
Danazol is only used for women whose condition has not responded to other forms of treatment. It is recommended that a treatment course should only last three to six months.
What is it used for?
* Endometriosis.
* Non-cancerous lumps in the breast (benign breast disease).
* A condition called hereditary angioedema – that can cause nettle rash and swelling around the eyes, mouth and hands (this is an unlicensed use of this medicine).
Use with caution in
* Liver disease.
* Kidney disease.
* Disease involving the heart and blood vessels (cardiovascular disease).
* High blood pressure (hypertension).
* Any condition/state made worse by fluid retention.
* Diabetes mellitus.
* Disorders of blood lipoproteins (fats, eg cholesterol).
* Excessive levels of red blood cells in the blood (polycythaemia).
* Epilepsy.
* Migraine.
* Malignant or cancerous disease.
* People who have previously developed severe or persistant masculine characteristics during treatment with sex steroid medicines such as this one.
Pregnancy and breastfeeding
Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
* This medicine may be harmful to an unborn baby and should not be used during pregnancy. Women who could get pregnant should use a non-hormonal method of contraception, eg condoms, to prevent pregnancy while taking this medicine.
* It is not known whether this medicine passes into breast milk. It should not be used by breastfeeding women because of the potential harm it may cause to nursing infants. Seek medical advice from your doctor.
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About the Author
Doctor Williams
Is Stanozolol still available in US pharmacies to be prescribed for hereditary angioedema?
Yes, with a prescription, in 2 mg tablets, under the name Winstrol. You should be advised that this medication tends to cause a significant rise in cholesterol and should not be taken by anyone who has a history of atherosclerotic heart disease. An alternative that has a cholesterol-lowering effect (so good, in fact, that it is used in Japan as a treatment for hypercholesterolemia) is Furzabol.
hereditary angioedema
